Tacrolimus

Please Note: Metkinen Oy is not manufacturing, offering or selling compound Tacrolimus.
Metkinen Oy is research and development organization focusing on bioprocess development.
At the moment, Metkinen Oy is researching the development of fermentation and downstream technology capable to produce Tacrolimus. Please request details on development progress

CAS number: 104987-11-3

Chemical Formula: C₄₄H₆₉NO₁₂·H₂O

Productivity: 0.5 – 0.7 G/L

Tacrolimus (also FK-506 or Fujimycin) is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. It is an immunosuppressive drug whose main use is after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection.

It has similar immunosuppressive properties to cyclosporine, but is much more potent in equal volumes. Also like cyclosporine it has a wide range of adverse interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with cyclisporine-based immunosuppression

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