Prednisolone

Product: Prednisolone (Prednisolonum) (pregnadiene-1,4-triol-11b, 17a, 21-dione-3,20, or D-1-dehydroxycortisone)
Strain: Non-pathogenic bacterial strain.
Substrate: Hydrocortisone (Cortisol)
Biotechnology parameters:

1. Substrate loading (kg per kg of product): less 1.2
2. Substrate concentration (g/l): >20 (up to 70)
3. Duration of microbial transformation stage: 5-8 hrs
4. Substrate conversion: 97-100 %
5. Yield of crystalline final product - >80%
6. Purity of product - corresponds to BP and USP requests

Biotechnology advantages:

• ecologically friendly
• high productivity
• high conversion degree (no residual substrate in a product)
• low labour- and energy consumes

Usage: Prednisolone is one of the most effective drugs of glucocorticoid group expressing inflammatory, desensibilic and anti-allergic activity. It is widely used in a therapy of different diseases - rheumatism, inflectional non-specific arthritis, asthma, lymphatic leucome, infectional mononucleosis, neurodermites, etc. The data were reported on effective prednisolone application at liver cirrhosis, chronicle glomerulonephritis, miasteny, etc.

Prednisolone is applied as API in drug formulations in forms of tablets, creams, eye and/or ear drops, injection solutions (as a hemisuccinate).

Prednisolone substance can be applied as a precursor in a synthesis of other steroid preparations (dexamethasone, triamcinolone, budesonide, etc.).

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